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Article

The impact of HIV-1 within-host evolution on transmission dynamics

21 Dec 2017

Abstract excerpt

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at...

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PMID: 29275182
DOI: 10.1016/j.coviro.2017.12.001

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