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The HIV-1 transmission bottleneck

23 Mar 2017

Abstract excerpt

It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor than to more abundant lineages. This has led to the widely accepted idea that transmission selects for viral characteristics that facilitate crossing the mucosal barrier of...

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PMID: 28335782
DOI: 10.1186/s12977-017-0343-8

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