Article
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
Science (New York, N.Y.) - 11 Jul 2014
Yu Min, Bardia Aditya, Aceto Nicola, Bersani Francesca, Madden Marissa W, Donaldson Maria C, Desai Rushil, Zhu Huili, Comaills Valentine, Zheng Zongli, Wittner Ben S, Stojanov Petar, Brachtel Elena, Sgroi Dennis, Kapur Ravi, Shioda Toshihiro, Ting David T, Ramaswamy Sridhar, Getz Gad, Iafrate A John, Benes Cyril, Toner Mehmet, Maheswaran Shyamala, Haber Daniel A
Abstract excerpt
Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the isolation, ex vivo culture, and characterization of CTCs may provide an opportunity to noninvasively monitor the changing patterns of drug susceptibility in individual patients as their tumors acquire new mutations. In a proof-of-concept study, we established CTC...
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