Article
Circulating tumor cells in breast cancer: functional heterogeneity, pathogenetic and clinical aspects.
Experimental oncology - 1 Mar 2017
Cherdyntseva N V, Litviakov N V, Denisov E V, Gervas P A, Cherdyntsev E S
Abstract excerpt
Each patient has a unique history of cancer ecosystem development, resulting in intratumor heterogeneity. In order to effectively kill the tumor cells by chemotherapy, dynamic monitoring of driver molecular alterations is necessary to detect the markers for acquired drug resistance and find the new therapeutic targets. To perform the therapeutic monitoring, frequent tumor biopsy is needed, but it is not always...
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