Article
Integrating ctDNA Dynamics and Sequential Organoid Drug Screening Enhances Breast Cancer Treatment Efficacy.
Cancer research - 2 Jan 2026
Liu Jialin, Fang Fang, Yuan Weiguang, Chen Tao, Wang Ji, Miao Xiaping, Meng Yuhuan, Song Chen, Tan Wanchun, An Jing, Nanding Abiyasi, Li Dalin, Zhang Youxue, Jiang Yongdong, Chen Yanbo, Xu Shouping, Zhang Guoqiang, Song Yanni, Li Hui, Gong Yajie, Yu Yuanyuan, Li Siwei, Zhang Xingda, Zhao Shilu, Hao Wenhui, Pang Da, Tian Jun, Yu Shihui, Zhang Xianyu
Abstract excerpt
Dynamic changes in ctDNA variant allele frequency reflect real-time therapeutic efficacy. Timely treatment modification guided by ctDNA variant allele frequency may enable precision selection of optimized regimens to counteract evolving resistance in breast cancer. In this study, we developed a therapeutic approach integrating ctDNA dynamics with sequential organoid drug screening to optimize breast cancer...
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