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Article

Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzheimer's disease in the Italian population.

Journal of the neurological sciences - 15 Sept 2014

Corbo Rosa Maria, Gambina Giuseppe, Broggio Elisabetta, Scarabino Daniela, Scacchi Renato

Abstract excerpt

The greater predisposition of women to Alzheimer's disease (AD), owing to the decrease in postmenopausal estrogen, may be influenced by polymorphic variation in genes regulating estrogen metabolism (e.g., COMT) and estrogen biosynthesis (e.g., CYP17). In order to better understand how the estrogen pathway genetic variation might affect AD onset, we conducted a case-control study of two single nucleotide...

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Source

Identifiers

PMID: 25012481
DOI: 10.1016/j.jns.2014.06.045

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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