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Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT.

Rejuvenation research - 1 Oct 2015

Scarabino Daniela, Scacchi Renato, Pinto Alessandro, Corbo Rosa Maria

Abstract excerpt

Evolutionary theories of aging predict an antagonistic relationship between fertility and life span in humans, but the genetic basis of this phenomenon is not clear. The variation of three genes in steroid hormone metabolism--CYP17 (rs743572), HSD17B1 (rs 605059), and COMT (rs4680)--was examined to elucidate the genetic basis of the relationship between fertility and life span. A sample of 277 individuals (mean...

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PMID: 25936248
DOI: 10.1089/rej.2015.1665

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COMT

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