Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis.

Journal of the American Society of Nephrology : JASN - 1 Jan 2015

Busnadiego Oscar, Loureiro-Álvarez Jesús, Sandoval Pilar, Lagares David, Dotor Javier, Pérez-Lozano María Luisa, López-Armada María J, Lamas Santiago, López-Cabrera Manuel, Rodríguez-Pascual Fernando

Abstract excerpt

In patients undergoing peritoneal dialysis (PD), chronic exposure to nonphysiologic PD fluids elicits low-grade peritoneal inflammation, leading to fibrosis and angiogenesis. Phenotype conversion of mesothelial cells into myofibroblasts, the so-called mesothelial-to-mesenchymal transition (MMT), significantly contributes to the peritoneal dysfunction related to PD. A number of factors have been described to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Endothelin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Fibrosis

Share to Gene Transfer Techniques

Share to Peritoneal Dialysis

Share to Peritoneum

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 25012164
DOI: 10.1681/ASN.2013070799
PMCID: PMC4279729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis.PMID 25012164Read ↗

Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage.Semantic proximity Read ↗

Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis.Semantic proximity Read ↗

Epithelial-to-mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport.Semantic proximity Read ↗

Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patientsSemantic proximity Read ↗

Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells.Semantic proximity Read ↗

Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells.Semantic proximity Read ↗

IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway.Semantic proximity Read ↗

Targeting STING in experimental peritoneal damage: a novel approach in peritoneal dialysis therapySemantic proximity Read ↗

Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis.Semantic proximity Read ↗

Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1.Semantic proximity Read ↗

MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport statusSemantic proximity Read ↗

p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.