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Article

Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells.

PloS one - 1 Jan 2012

Strippoli Raffaele, Benedicto Ignacio, Perez Lozano Maria Luisa, Pellinen Teijo, Sandoval Pilar, Lopez-Cabrera Manuel, del Pozo Miguel Angel

Abstract excerpt

Peritoneal fibrosis is a frequent complication of peritoneal dialysis following repeated low grade inflammatory and pro-fibrotic insults. This pathological process may lead to ultrafiltration failure and eventually to the discontinuing of the therapy. Fibrosis is linked to epithelial to mesenchymal transition (EMT) of the peritoneal mesothelial cells, which acquire invasive and fibrogenic abilities. Here, we...

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Identifiers

PMID: 22384029
DOI: 10.1371/journal.pone.0031492
PMCID: PMC3288041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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