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Article

Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage.

Journal of the American Society of Nephrology : JASN - 1 Sept 2011

Loureiro Jesús, Aguilera Abelardo, Selgas Rafael, Sandoval Pilar, Albar-Vizcaíno Patricia, Pérez-Lozano María Luisa, Ruiz-Carpio Vicente, Majano Pedro L, Lamas Santiago, Rodríguez-Pascual Fernando, Borras-Cuesta Francisco, Dotor Javier, López-Cabrera Manuel

Abstract excerpt

During peritoneal dialysis (PD), mesothelial cells undergo mesothelial-to-mesenchymal transition (MMT), a process associated with peritoneal-membrane dysfunction. Because TGF-β1 can induce MMT, we evaluated the efficacy of TGF-β1-blocking peptides in modulating MMT and ameliorating peritoneal damage in a mouse model of PD. Exposure of the peritoneum to PD fluid induced fibrosis, angiogenesis, functional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21742730
DOI: 10.1681/ASN.2010111197
PMCID: PMC3171939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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