Article
Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage.
Journal of the American Society of Nephrology : JASN - 1 Sept 2011
Loureiro Jesús, Aguilera Abelardo, Selgas Rafael, Sandoval Pilar, Albar-Vizcaíno Patricia, Pérez-Lozano María Luisa, Ruiz-Carpio Vicente, Majano Pedro L, Lamas Santiago, Rodríguez-Pascual Fernando, Borras-Cuesta Francisco, Dotor Javier, López-Cabrera Manuel
Abstract excerpt
During peritoneal dialysis (PD), mesothelial cells undergo mesothelial-to-mesenchymal transition (MMT), a process associated with peritoneal-membrane dysfunction. Because TGF-β1 can induce MMT, we evaluated the efficacy of TGF-β1-blocking peptides in modulating MMT and ameliorating peritoneal damage in a mouse model of PD. Exposure of the peritoneum to PD fluid induced fibrosis, angiogenesis, functional...
Topics
- Animals
- Biomarkers
- Cell Transdifferentiation
- Cells, Cultured
- Dialysis Solutions
- Female
- Injections, Intraperitoneal
- Keratins
- Mice
- Mice, Inbred C57BL