Article
Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells.
Matrix biology : journal of the International Society for Matrix Biology - 1 Mar 2010
Patel Pranali, West-Mays Judy, Kolb Martin, Rodrigues Juan-Carlos, Hoff Catherine M, Margetts Peter J
Abstract excerpt
Platelet derived growth factor (PDGF) is involved in wound healing in various organ systems. Its potential role in the context of peritoneal injury following long-term peritoneal dialysis is unclear. We used an adenovirus expressing the B chain of PDGF (AdPDGF-B) to assess its effect on pro-fibrotic pathways in the peritoneal membrane. To assess the transforming growth factor (TGF) beta independent effects of...
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