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Article

Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis.

PloS one - 1 Jan 2013

Loureiro Jesús, Sandoval Pilar, del Peso Gloria, Gónzalez-Mateo Guadalupe, Fernández-Millara Vanessa, Santamaria Beatríz, Bajo Maria Auxiliadora, Sánchez-Tomero José Antonio, Guerra-Azcona Gonzalo, Selgas Rafael, López-Cabrera Manuel, Aguilera Abelardo I

Abstract excerpt

Mesothelial-to-mesenchymal transition (MMT) is an auto-regulated physiological process of tissue repair that in uncontrolled conditions such as peritoneal dialysis (PD) can lead to peritoneal fibrosis. The maximum expression of peritoneal fibrosis induced by PD fluids and other peritoneal processes is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. Tamoxifen, a synthetic...

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Identifiers

PMID: 23637793
DOI: 10.1371/journal.pone.0061165
PMCID: PMC3634067

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