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Article

The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence.

Fungal genetics and biology : FG & B - 1 Sept 2014

de Gontijo Fabiano Assis, Pascon Renata C, Fernandes Larissa, Machado Joel, Alspaugh J Andrew, Vallim Marcelo A

Abstract excerpt

Fungal infections are often difficult to treat due to the inherent similarities between fungal and animal cells and the resulting host toxicity from many antifungal compounds. Cryptococcus neoformans is an opportunistic fungal pathogen of humans that causes life-threatening disease, primarily in immunocompromised patients. Since antifungal therapy for this microorganism is limited, many investigators have...

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Identifiers

PMID: 25011011
DOI: 10.1016/j.fgb.2014.06.003
PMCID: PMC4286198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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