Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.

Infection and immunity - 1 Oct 2006

Petzold Elizabeth Wills, Himmelreich Uwe, Mylonakis Eleftherios, Rude Thomas, Toffaletti Dena, Cox Gary M, Miller Jackie L, Perfect John R

Abstract excerpt

The disaccharide trehalose has been found to play diverse roles, from energy source to stress protectant, and this sugar is found in organisms as diverse as bacteria, fungi, plants, and invertebrates but not in mammals. Recent studies in the pathobiology of Cryptococcus neoformans identified the presence of a functioning trehalose pathway during infection and suggested its importance for C. neoformans survival in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryptococcosis
Share to Cryptococcus neoformans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucosyltransferases

Share to Glycolysis

Share to Rabbits

Share to Sorbitol

Share to Sugar Phosphates

Share to Trehalose

Source

Open in PubMed Open full text

Identifiers

PMID: 16988267
DOI: 10.1128/IAI.00624-06
PMCID: PMC1594924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.PMID 16988267Read ↗

Developmental Cell Fate and Virulence Are Linked to Trehalose Homeostasis in Cryptococcus neoformansSemantic proximity Read ↗

Cryptococcus neoformans trehalose-6-phosphate synthase (tps1) promotes organ-specific virulence and fungal protection against multiple lines of host defensesSemantic proximity Read ↗

Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.Semantic proximity Read ↗

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.Semantic proximity Read ↗

Disruption of the <i>Candida albicans TPS2</i> Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha FormationSemantic proximity Read ↗

Trehalose-6-phosphate synthase promotes thermotolerance by governing glycolytic flux in <i>Cryptococcus deneoformans</i>Semantic proximity Read ↗

The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase.Semantic proximity Read ↗

Amino Acid Permeases and Virulence in Cryptococcus neoformans.Semantic proximity Read ↗

Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulenceSemantic proximity Read ↗

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>Semantic proximity Read ↗

Cryptococcal nutrient acquisition and pathogenesis: dining on the hostSemantic proximity Read ↗

Evaluating cellular roles and phenotypes associated with trehalose degradation genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.