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Article

Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro

17 Apr 2020

Abstract excerpt

Significance The incidence of infections due to fungal pathogens has dramatically increased in human populations with weakened or suppressed immune systems. Understanding how organisms rapidly adapt during human infection to enhance virulence and evolve drug resistance is important for developing effective treatments. We find that transposon mobilization in the human pathogen Cryptococcus causes genomic mutations...

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Share to Antifungal resistance and susceptibility
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PMID: 32303657
DOI: 10.1073/pnas.2001451117

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