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Article

HS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strain.

BioMed research international - 1 Jan 2014

Montesano Carla, Giambra Vincenzo, Frezza Domenico, Palma Paolo, Serone Eliseo, Gattinara Guido Castelli, Mattei Maurizio, Mancino Giorgio, Colizzi Vittorio, Amicosante Massimo

Abstract excerpt

Alteration in the humoral immune response has been observed during HIV infection. The polymorphisms of enhancer HS1,2, member of the 3(') regulatory region of the Ig heavy chain cluster, may play a role in the variation of the humoral response leading to pathological conditions. To assess the role of the HS1,2 polymorphic variants in the progression of AIDS, the HS1,2-A allelic frequencies were investigated in a...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

Share to Immunity, Humoral

Share to Immunoglobulin Heavy Chains

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Source

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Identifiers

PMID: 25009819
DOI: 10.1155/2014/637523
PMCID: PMC4055013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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