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Article

Construction and characteristics of an E-cadherin-related three-dimensional suspension growth model of ovarian cancer

10 Jul 2014

Abstract excerpt

Ovarian cancer is the deadliest of all gynecologic malignancies. Metastatic ovarian cancer cells exist mainly in the form of multi-cellular spheroids (MCSs) in the ascites of patients with advanced ovarian cancer. We hypothesized that E-cadherin, as an important cell-adhesion molecule, might play an important role in the formation and survival of MCSs. Therefore, we established a three-dimensional suspension...

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PMID: 25008268
DOI: 10.1038/srep05646

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