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Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

31 Oct 2005

Abstract excerpt

Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis. Immunoreactive iNOS was detected in brains of mice with AD-like disease resulting from transgenic expression of mutant human beta-amyloid precursor protein (hAPP) and presenilin-1 (hPS1). We bred hAPP-, hPS1-double transgenic mice to be iNOS(+/+)...

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PMID: 16260491
DOI: 10.1084/jem.20051529

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