Article
t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast.
The EMBO journal - 1 Feb 2001
Marash M, Gerst J E
Abstract excerpt
The role of protein phosphorylation in secretion is not well understood. Here we show that yeast lacking the Snc1,2 v-SNAREs, or bearing a temperature-sensitive mutation in the Sso2 t-SNARE, are rescued at restrictive conditions by the addition of ceramide precursors and analogs to the growth medium. Rescue results from dephosphorylation of the Sso t-SNAREs by a ceramide-activated type 2A protein phosphatase...
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