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Article

TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast.

The Journal of biological chemistry - 21 Aug 2020

Schmidt Oliver, Weyer Yannick, Sprenger Simon, Widerin Michael A, Eising Sebastian, Baumann Verena, Angelova Mihaela, Loewith Robbie, Stefan Christopher J, Hess Michael W, Fröhlich Florian, Teis David

Abstract excerpt

The endosomal sorting complexes required for transport (ESCRT) mediate evolutionarily conserved membrane remodeling processes. Here, we used budding yeast (Saccharomyces cerevisiae) to explore how the ESCRT machinery contributes to plasma membrane (PM) homeostasis. We found that in response to reduced membrane tension and inhibition of TOR complex 2 (TORC2), ESCRT-III/Vps4 assemblies form at the PM and help...

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Identifiers

PMID: 32611771
DOI: 10.1074/jbc.RA120.013222
PMCID: PMC7443507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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