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Article

Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix.

Molecular and cellular biology - 15 Sept 2014

Melin Jonathan, Schulz Christian, Wrobel Lidia, Bernhard Olaf, Chacinska Agnieszka, Jahn Olaf, Schmidt Bernhard, Rehling Peter

Abstract excerpt

More than 70% of mitochondrial proteins utilize N-terminal presequences as targeting signals. Presequence interactions with redundant cytosolic receptor domains of the translocase of the outer mitochondrial membrane (TOM) are well established. However, after the presequence enters the protein-conducting Tom40 channel, the recognition events that occur at the trans side leading up to the engagement of the...

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Identifiers

PMID: 25002531
DOI: 10.1128/MCB.00433-14
PMCID: PMC4135617

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Source receipt: pubmed, retrieved 7 Sept 2026.

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