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Article

Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014

Quéré Ronan, Saint-Paul Laetitia, Carmignac Virginie, Martin Romain Z, Chrétien Marie-Lorraine, Largeot Anne, Hammann Arlette, Pais de Barros Jean-Paul, Bastie Jean-Noël, Delva Laurent

Abstract excerpt

The hematopoietic system declines with age. Myeloid-biased differentiation and increased incidence of myeloid malignancies feature aging of hematopoietic stem cells (HSCs), but the mechanisms involved remain uncertain. Here, we report that 4-mo-old mice deleted for transcription intermediary factor 1γ (Tif1γ) in HSCs developed an accelerated aging phenotype. To reinforce this result, we also show that Tif1γ is...

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Identifiers

PMID: 25002492
DOI: 10.1073/pnas.1405546111
PMCID: PMC4115559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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