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Article

Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.

PloS one - 1 Jan 2014

Lin Tzung-Yi, Chou Chi-Fu, Chung Hsin-Yu, Chiang Chia-Yin, Li Chung-Hao, Wu Jen-Leih, Lin Han-Jia, Pai Tun-Wen, Hu Chin-Hwa, Tzou Wen-Shyong

Abstract excerpt

The liver plays a vital role in metabolism, detoxification, digestion, and the maintenance of homeostasis. During development, the vertebrate embryonic liver undergoes a series of morphogenic processes known as hepatogenesis. Hepatogenesis can be separated into three interrelated processes: endoderm specification, hepatoblast differentiation, and hepatic outgrowth. Throughout this process, signaling molecules and...

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PMID: 25000307
DOI: 10.1371/journal.pone.0101980
PMCID: PMC4084947

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Source receipt: pubmed, retrieved 7 Sept 2026.

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