Article
Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.
PLoS genetics - 1 Feb 2016
Hu Minjie, Bai Yun, Zhang Chunxia, Liu Feng, Cui Zongbin, Chen Jun, Peng Jinrong
Abstract excerpt
Unlike mammals and birds, teleost fish undergo external embryogenesis, and therefore their embryos are constantly challenged by stresses from their living environment. These stresses, when becoming too harsh, will cause arrest of cell proliferation, abnormal cell death or senescence. Such organisms have to evolve a sophisticated anti-stress mechanism to protect the process of embryogenesis/organogenesis. However,...
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