Article
Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish.
PloS one - 28 Aug 2008
Kamei Hiroyasu, Lu Ling, Jiao Shuang, Li Yun, Gyrup Claus, Laursen Lisbeth S, Oxvig Claus, Zhou Jianfeng, Duan Cunming
Abstract excerpt
BACKGROUND: Gene duplication is the primary force of new gene evolution. Deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging. The zebrafish is uniquely positioned to provide insight into the process of functional gene evolution due to its amenability to genetic and experimental manipulation and because it possess a large number of duplicated genes....
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