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Article

A unification of mediation and interaction: a 4-way decomposition.

Epidemiology (Cambridge, Mass.) - 1 Sept 2014

VanderWeele Tyler J

Abstract excerpt

The overall effect of an exposure on an outcome, in the presence of a mediator with which the exposure may interact, can be decomposed into 4 components: (1) the effect of the exposure in the absence of the mediator, (2) the interactive effect when the mediator is left to what it would be in the absence of exposure, (3) a mediated interaction, and (4) a pure mediated effect. These 4 components, respectively,...

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Identifiers

PMID: 25000145
DOI: 10.1097/EDE.0000000000000121
PMCID: PMC4220271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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