Article
Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo.
Breast cancer research : BCR - 6 Jul 2014
Klevebring Daniel, Rosin Gustaf, Ma Ran, Lindberg Johan, Czene Kamila, Kere Juha, Fredriksson Irma, Bergh Jonas, Hartman Johan
Abstract excerpt
INTRODUCTION: The cancer stem cell model implies a hierarchical organization within breast tumors maintained by cancer stem-like cells (CSCs). Accordingly, CSCs are a subpopulation of cancer cells with capacity for self-renewal, differentiation and tumor initiation. These cells can be isolated through the phenotypic markers CD44+/CD24-, expression of ALDH1 and an ability to form nonadherent, multicellular spheres...
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