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Article

Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation.

Human pathology - 1 Sept 2014

Hershkovitz Dov, Simon Einav, Bick Tova, Prinz Elad, Noy Shawna, Sabo Edmond, Ben-Izhak Ofer, Vieth Michael

Abstract excerpt

Activating mutations in KRAS are common events in the pathogenesis of colorectal carcinoma and predict response to treatment with anti-EGFR antibodies. Molecular pathology testing for KRAS mutations has become the standard of practice for patients with metastatic colorectal carcinoma. Despite the known histologic and molecular differences between adenomas and carcinomas, the concordance of KRAS mutation between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24998492
DOI: 10.1016/j.humpath.2014.05.005

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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