Article
Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain.
Biochemistry - 29 Mar 2011
Kawahara Tsukasa, Jackson Heather M, Smith Susan M E, Simpson Paul D, Lambeth J David
Abstract excerpt
Nox5 belongs to the calcium-regulated subfamily of NADPH oxidases (Nox). Like other calcium-regulated Noxes, Nox5 has an EF-hand-containing calcium-binding domain at its N-terminus, a transmembrane heme-containing region, and a C-terminal dehydrogenase (DH) domain that binds FAD and NADPH. While Nox1-4 require regulatory subunits, including p22phox, Nox5 activity does not depend on any subunits. We found that...
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