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Article

DNA topoisomerase 1α promotes transcriptional silencing of transposable elements through DNA methylation and histone lysine 9 dimethylation in Arabidopsis.

PLoS genetics - 1 Jul 2014

Dinh Thanh Theresa, Gao Lei, Liu Xigang, Li Dongming, Li Shengben, Zhao Yuanyuan, O'Leary Michael, Le Brandon, Schmitz Robert J, Manavella Pablo A, Manavella Pablo, Li Shaofang, Weigel Detlef, Pontes Olga, Ecker Joseph R, Chen Xuemei

Abstract excerpt

RNA-directed DNA methylation (RdDM) and histone H3 lysine 9 dimethylation (H3K9me2) are related transcriptional silencing mechanisms that target transposable elements (TEs) and repeats to maintain genome stability in plants. RdDM is mediated by small and long noncoding RNAs produced by the plant-specific RNA polymerases Pol IV and Pol V, respectively. Through a chemical genetics screen with a luciferase-based DNA...

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Share to DNA Topoisomerases, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24992598
DOI: 10.1371/journal.pgen.1004446
PMCID: PMC4080997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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