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Article

WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells

3 Jul 2014

Abstract excerpt

Members of the WD-repeat protein interacting with phosphoinositides (WIPI) family are phosphatidylinositol 3-phosphate (PI3P) effectors that are essential for the formation of autophagosomes. Autophagosomes, unique double-membraned organelles, are characteristic for autophagy, a bulk degradation mechanism with cytoprotective and homeostatic function. Both, WIPI-1 and WIPI-2 are aberrantly expressed in several...

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PMID: 24991767
DOI: 10.1038/cddis.2014.261

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