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Article

The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia

6 Dec 2017

Abstract excerpt

The E3 ubiquitin ligase (E3) WWP1 is an oncogenic factor implicated in the maintenance of different types of epithelial cancers. The role of WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in haematological neoplasms remains unknown. Acute myeloid leukaemia (AML) is characterized by the expansion of malignant myeloid cells blocked at different stages of differentiation. Here we report that the...

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PMID: 29209041
DOI: 10.1038/leu.2017.342

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