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Article

Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy.

Oxidative medicine and cellular longevity - 1 Jan 2018

Jin Jing, Britschgi Adrian, Schläfli Anna M, Humbert Magali, Shan-Krauer Deborah, Batliner Jasmin, Federzoni Elena A, Ernst Marion, Torbett Bruce E, Yousefi Shida, Simon Hans-Uwe, Tschan Mario P

Abstract excerpt

Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. We found a significantly lower expression of key autophagy-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Line, Tumor

Share to ATG5 gene

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29743969
DOI: 10.1155/2018/1482795
PMCID: PMC5878891

Genes

ATG3
ATG5
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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