MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.

doi:10.3945/ajcn.113.076992

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Article

MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.

The American journal of clinical nutrition - 1 Aug 2014

Corella Dolores, Sorlí Jose V, Estruch Ramon, Coltell Oscar, Ortega-Azorín Carolina, Portolés Olga, Martínez-González Miguel Ángel, Bulló Mónica, Fitó Montserrat, Arós Fernando, Lapetra José, Asensio Eva M, Sáez Guillermo T, Serra-Majem Lluís, Muñoz-Bravo Carlos, Ruiz-Gutiérrez Valentina, Fiol Miquel, Vinyoles Ernest, Pintó Xavier, Richardson Kris, Ros Emilio, Ordovás Jose M

Abstract excerpt

BACKGROUND: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat...

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PMID: 24990426
DOI: 10.3945/ajcn.113.076992

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