Article
Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.
American journal of human genetics - 10 Jan 2013
Richardson Kris, Nettleton Jennifer A, Rotllan Noemi, Tanaka Toshiko, Smith Caren E, Lai Chao-Qiang, Parnell Laurence D, Lee Yu-Chi, Lahti Jari, Lemaitre Rozenn N, Manichaikul Ani, Keller Margaux, Mikkilä Vera, Ngwa Julius, van Rooij Frank J A, Ballentyne Christie M, Borecki Ingrid B, Cupples L Adrienne, Garcia Melissa, Hofman Albert, Ferrucci Luigi, Mozaffarian Dariush, Perälä Mia-Maria, Raitakari Olli, Tracy Russell P, Arnett Donna K, Bandinelli Stefania, Boerwinkle Eric, Eriksson Johan G, Franco Oscar H, Kähönen Mika, Nalls Michael, Siscovick David S, Houston Denise K, Psaty Bruce M, Viikari Jorma, Witteman Jacqueline C M, Goodarzi Mark O, Lehtimäki Terho, Liu Yongmei, Zillikens M Carola, Chen Yii-Der I, Uitterlinden André G, Rotter Jerome I, Fernandez-Hernando Carlos, Ordovas Jose M
Abstract excerpt
Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the association of the lipoprotein lipase (LPL) variant rs13702 with plasma lipids and explored its potential for functionality. The rs13702 minor allele had been...
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