Article
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial.
BMC medical genetics - 29 Jun 2011
Smart-Halajko Melissa C, Kelley-Hedgepeth Alyson, Montefusco Maria Claudia, Cooper Jackie A, Kopin Alan, McCaffrey Jeanne M, Balasubramanyam Ashok, Pownall Henry J, Nathan David M, Peter Inga, Talmud Philippa J, Huggins Gordon S
Abstract excerpt
BACKGROUND: Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In non-diabetic individuals, the ANGPTL4 coding variant E40K has been associated with lower plasma triglyceride levels while the T266M variant has been associated with more modest effects on...
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