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Article

Prognostic significance of hMLH1/hMSH2 gene mutations and hMLH1 promoter methylation in sporadic colorectal cancer.

Medical oncology (Northwood, London, England) - 1 Jul 2014

Wang Yibaina, Li Dandan, Li Xia, Teng Chong, Zhu Lin, Cui Binbin, Zhao Yashuang, Hu Fulan

Abstract excerpt

No study in China has focused on the relationships between germline and somatic hMLH1/hMSH2 gene mutations, hMLH1 promoter methylation, and the prognosis of colorectal cancer (CRC), especially in sporadic CRC. Therefore, we carried out this study with 433 primary sporadic CRC patients to investigate the associations between germline and somatic hMLH1/hMSH2 gene mutations, hMLH1 promoter methylation, and the...

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PMID: 24990217
DOI: 10.1007/s12032-014-0039-z

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