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Article

Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.

BMC medical genetics - 7 Apr 2011

de Souza Fladjule Rejane Soares, Fontes Fabrícia Lima, da Silva Thayse Azevedo, Coutinho Leonam Gomes, Leib Stephen L, Agnez-Lima Lucymara Fassarella

Abstract excerpt

BACKGROUND: The kynurenine (KYN) pathway has been shown to be altered in several diseases which compromise the central nervous system (CNS) including infectious diseases such as bacterial meningitis (BM). The aim of this study was to assess single nucleotide polymorphisms (SNPs) in four genes of KYN pathway in patients with meningitis and their correlation with markers of immune response in BM. METHODS: One...

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Source

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Identifiers

PMID: 21473761
DOI: 10.1186/1471-2350-12-51
PMCID: PMC3084162

Genes

AADAT
KYNU
IDO1
MIP
CCL4
TNF

Provenance

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