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Article

Risk of pediatric celiac disease according to HLA haplotype and country.

The New England journal of medicine - 3 Jul 2014

Liu Edwin, Lee Hye-Seung, Aronsson Carin A, Hagopian William A, Koletzko Sibylle, Rewers Marian J, Eisenbarth George S, Bingley Polly J, Bonifacio Ezio, Simell Ville, Agardh Daniel

Abstract excerpt

BACKGROUND: The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG). METHODS: We studied 6403 children with HLA haplotype DR3-DQ2 or DR4-DQ8 prospectively from birth in the United States, Finland, Germany, and Sweden. The primary end point was the...

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Identifiers

PMID: 24988556
DOI: 10.1056/NEJMoa1313977
PMCID: PMC4163840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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