Article
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.
PloS one - 1 Jan 2016
Sharma Ashok, Liu Xiang, Hadley David, Hagopian William, Liu Edwin, Chen Wei-Min, Onengut-Gumuscu Suna, Simell Ville, Rewers Marian, Ziegler Anette-G, Lernmark Åke, Simell Olli, Toppari Jorma, Krischer Jeffrey P, Akolkar Beena, Rich Stephen S, Agardh Daniel, She Jin-Xiong
Abstract excerpt
OBJECTIVES: There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international prospective cohort...
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