Article
Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2017
Kemppainen Kaisa M, Lynch Kristian F, Liu Edwin, Lönnrot Maria, Simell Ville, Briese Thomas, Koletzko Sibylle, Hagopian William, Rewers Marian, She Jin-Xiong, Simell Olli, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Krischer Jeffrey P, Lernmark Åke, Hyöty Heikki, Triplett Eric W, Agardh Daniel
Abstract excerpt
BACKGROUND & AIMS: Little is known about the pathogenic mechanisms of gluten immunogenicity in patients with celiac disease. We studied temporal associations between infections and the development of celiac disease autoimmunity, and examined effects of HLA alleles, rotavirus vaccination status, and infant feeding. METHODS: We monitored 6327 children in the United States and Europe carrying HLA risk genotypes for...
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