Article

Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapy

2024-09-14

Abstract excerpt

Tumor heterogeneity and plasticity, driven by Epithelial-Mesenchymal Transition (EMT), enable cancer therapeutic resistance. We previously showed that EMT promotes primary cilia formation, which enables stemness and tumorigenesis in triple-negative breast cancer (TNBC). Here, we establish a role for primary cilia in human TNBC chemotherapeutic resistance. We developed patient-derived organoids, and showed that the...

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Literature Corpus work: b4681a53-2c56-5788-9f42-6d2b6d77a1c0
DOI: 10.1101/2024.09.10.612175

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