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Article

Factor XIII, clot structure, thrombosis.

Thrombosis research - 1 Mar 2012

Bagoly Zsuzsa, Koncz Zsuzsa, Hársfalvi Jolán, Muszbek László

Abstract excerpt

Blood coagulation factor XIII (FXIII) is a tetrameric protein consisting of two catalytic A (FXIII-A) and two carrier/inhibitory B (FXIII-B) subunits. It is a zymogen, which becomes transformed into an active transglutaminase (FXIIIa) in the final phase of coagulation cascade by thrombin and Ca(2+). FXIII is essential for hemostasis, its deficiency results in severe bleeding diathesis. FXIIIa mechanically...

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PMID: 22197181
DOI: 10.1016/j.thromres.2011.11.040

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