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Article

A single nucleotide incorporation step limits human telomerase repeat addition activity.

The EMBO journal - 15 Mar 2018

Chen Yinnan, Podlevsky Joshua D, Logeswaran Dhenugen, Chen Julian J-L

Abstract excerpt

Human telomerase synthesizes telomeric DNA repeats (GGTTAG)n onto chromosome ends using a short template from its integral telomerase RNA (hTR). However, telomerase is markedly slow for processive DNA synthesis among DNA polymerases. We report here that the unique template-embedded pause signal restricts the first nucleotide incorporation for each repeat synthesized, imparting a significantly greater KM This slow...

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Identifiers

PMID: 29440226
DOI: 10.15252/embj.201797953
PMCID: PMC5852417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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