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Article

Alteration of the substrate specificity of cytochrome P450 CYP199A2 by site-directed mutagenesis.

Journal of bioscience and bioengineering - 1 Jan 2015

Furuya Toshiki, Shitashima Yoh, Kino Kuniki

Abstract excerpt

CYP199A2, a member of the cytochrome P450 family, is a monooxygenase that specializes in the oxidation of aromatic carboxylic acids. The crystal structure of CYP199A2 determined by Bell et al. (J. Mol. Biol., 383, 561-574, 2008) suggested that the S97 and S247 residues conferred the substrate specificity on this enzyme through interaction between the hydroxy side chains of these Ser residues and the carboxy group...

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Source

Identifiers

PMID: 24982017
DOI: 10.1016/j.jbiosc.2014.05.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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