Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults.

doi:10.1007/s11357-014-9664-x

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Article

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults.

Age (Dordrecht, Netherlands) - 1 Jan 2014

Salminen Lauren E, Schofield Peter R, Pierce Kerrie D, Conturo Thomas E, Tate David F, Lane Elizabeth M, Heaps Jodi M, Bolzenius Jacob D, Baker Laurie M, Akbudak Erbil, Paul Robert H

Abstract excerpt

Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact of AGTR1 A1166C on white matter integrity and...

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Identifiers

PMID: 24981111
DOI: 10.1007/s11357-014-9664-x
PMCID: PMC4150909

Genes

AGTR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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