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Article

NNK reduction pathway gene polymorphisms and risk of lung cancer.

Molecular carcinogenesis - 1 Jun 2015

Modesto Jennifer L, Hull Anna, Angstadt Andrea Y, Berg Arthur, Gallagher Carla J, Lazarus Philip, Muscat Joshua E

Abstract excerpt

The tobacco-specific nitrosamine NNK is a potent carcinogen found in tobacco smoke and implicated in the development of lung cancer. The major route of NNK metabolism is carbonyl reduction by AKR1C1, AKR1C2, CBR1, and 11β-HSD1 to form NNAL. This study investigated the potential role of variants in this pathway on lung cancer risk by examining 53 tag-SNPs representing the common variations in AKR1C1, AKR1C2, CBR1,...

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Source

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Identifiers

PMID: 24976539
DOI: 10.1002/mc.22187
PMCID: PMC6296469

Genes

CBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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