Article
Novel integrative genomics strategies to identify genes for complex traits.
Animal genetics - 1 Aug 2006
Schadt E E
Abstract excerpt
Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the identification of genes that have incurred mutations over the course of evolution or that incurred mutations as a result...
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