Article
Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.
Addiction biology - 1 Nov 2014
Dick Danielle M, Cho Seung Bin, Latendresse Shawn J, Aliev Fazil, Nurnberger John I, Edenberg Howard J, Schuckit Marc, Hesselbrock Victor M, Porjesz Bernice, Bucholz Kathleen, Wang Jen-Chyong, Goate Alison, Kramer John R, Kuperman Samuel
Abstract excerpt
Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use...
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