Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.

doi:10.1371/journal.pone.0098815

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Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.

PloS one - 1 Jan 2014

Bank Steffen, Skytt Andersen Paal, Burisch Johan, Pedersen Natalia, Roug Stine, Galsgaard Julie, Ydegaard Turino Stine, Brodersen Jacob Broder, Rashid Shaista, Kaiser Rasmussen Britt, Avlund Sara, Bastholm Olesen Thomas, Jürgen Hoffmann Hans, Kragh Thomsen Marianne, Ostergaard Thomsen Vibeke, Frydenberg Morten, Andersen Nexø Bjørn, Sode Jacob, Vogel Ulla, Andersen Vibeke

Abstract excerpt

BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the genetic heritage. METHODS: Using a candidate gene approach, 39 mainly functional single nucleotide polymorphisms (SNPs) in 26 genes regulating inflammation were...

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Identifiers

PMID: 24971461
DOI: 10.1371/journal.pone.0098815
PMCID: PMC4074037

Genes

PTPN22
TLR2
TLR4
TLR9
NFKB1
NFKBIA
PPARG

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.PMID 24971461Read ↗

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